Targeting ‘undruggable’ leukemia proteins

Ani Deshpande, PhD at Sanford Burnham Prebys Medical Discovery Institute in California is working to target previously ‘undruggable’ proteins in acute lymphoblastic leukemia. The problem: Research helps kids like Liam, who is fighting ALL. Click to read “Leukemia and Lightsabers – Liam’s Story.” Some types of childhood leukemia have two genes that fuse together to form a cancer-causing fusion protein. Some of these fusions proteins …

Treating Leukemia with Microbubbles

Texas Caroline de Gracia Lux , PhD at the University of Texas, Southwestern in Texas will use novel ultrasound technology to make acute lymphoblastic leukemia CAR-T cell treatment less toxic and improve the quality of life during treatment.  The problem: Currently, CAR T-cell immunotherapy is the best way to cure relapsed acute lymphoblastic leukemia, one of the most common cancers in children. Unfortunately, this type of …

Targeting Chemoresistant Leukemia Cells

Sometimes, leukemia cancer cells are so powerful they can overcome the most potent of chemotherapies. Because of support in part by Children’s Cancer Research Fund’s donors, Peter Gordon, MD, PhD, an oncologist and researcher at the University of Minnesota, and his team could explore the reasons this happens, opening potential new avenues for treatment options for acute lymphoblastic leukemia (ALL) and more. According to Dr. …

Leukemia and Lightsabers – Liam’s Story

Plenty of 5-year-old boys get bumps and scrapes, but when Kristy started noticing more bruises than normal on her son Liam, she mentioned it to his doctor. After checking the levels in his blood, Liam’s doctor told Kristy that something was definitely off. Kristy’s heart sank. Kristy and her husband Stan took Liam to the hospital that day. After more tests, their suspicions were confirmed …

Leukemia

Leukemia and other diseases of the blood and bone marrow may affect red blood cells, white blood cells and platelets. Treatment for children with leukemia is tailored to each child, depending on their illness. Chemotherapy and radiation are often used. At times, a blood or marrow transplantation (BMT) may be recommended.