The power of seed funding: CCRF-funded leukemia screening project lands NIH grant

Noah, leukemia survivor

Erin Marcotte, PhD, MPH, and Heather Nelson, PhD, MPH, of University of Minnesota are seizing the opportunity to turn small things into big hope for the future of childhood leukemia. In 2016, the pair received a grant from Children’s Cancer Research Fund (CCRF) to develop a new method to predict which children are at risk of developing acute lymphoblastic leukemia (ALL) — and perhaps one day prevent it.

Developing a new way to stop the most aggressive leukemia

With support from an Accelerating Impact for Hard-to-Treat Cancer Award from Children’s Cancer Research Fund (CCRF), University of Virginia researcher John Bushweller is pursuing an innovative new way to treat this devastating disease. Bushweller has found that blocking the MLL protein from binding to DNA stops leukemia cell growth completely — like corking a bottle so that nothing can spill out. Now he and his team at UVA Cancer Center are developing drugs to disrupt the DNA binding process.

Looking Through a Window – Finley’s Story with Leukemia

Four-year-old Finley isn’t used to silence, even as the introverted twin. At home, he lives with his energetic twin sister named Emerson, his parents, Devan and Becky, three cats and three dogs. “It’s kind of like a mini zoo, but we like it that way,” said Becky. So, when Finley found himself in the hospital Facetiming his sister, whom he’d never been without, it made …

Callen’s Story: Rare Leukemia and the Promise of a Pool Day

Callen’s mom, Tori, describes her 2-year-old son as a sour patch kid, “But when he’s sweet,” she said, “he’s really sweet.”  The compassion he’s shown her throughout his acute myeloid leukemia (AML) diagnosis, for example, is something she’ll hold onto for the rest of her life. “Whenever I get into a little funk and I start crying because I’m sad over this, he sits up, …

Cayden’s Story – Fighting Leukemia

Every morning when Courtney wakes up her 6-year-old son Cayden, she just holds him in her lap for a few minutes. She studies the features of his face, sometimes stroking an eyebrow or touching the curl of his hair. She remembers to be grateful for whatever the day ahead holds. Three years ago, Courtney may have taken these kinds of moments for granted, but not …

Noah’s Story – Fighting Acute Lymphoblastic Leukemia

Two-year-old Noah is very much the baby of the family – his six older siblings love giving him attention and watching him learn new things. He usually has lots of energy, so when he started acting a little lethargic and a black eye he’d gotten from playing wasn’t going away, his parents, Amy and Ryan, scheduled a doctor’s appointment to see what was going on.

The Race Against Rare Leukemia 

The Race Against Rare Leukemia Donors like you helped to create a treatment where one has never existed before. Thanks to your generous support we have reached our goal to bring this promising treatment to kids like Ella through a groundbreaking clinical trial! Read more about about this exciting milestone. Check back for updates on the trial launch in 2024.You can change the course of …

Flipping the “switch” that powers aggressive MLL-r leukemia

Linda Resar, MD, will never forget Amanda, the first leukemia patient she cared for during her oncology fellowship. The inspirational 8-year-old, who had Down syndrome, was fighting acute lymphocytic leukemia. “She was exceptionally courageous, thoughtful and resilient,” Resar said. “While she was cured and is now in her 30s, the chemotherapy was toxic, and she became ill throughout the treatment, which drives me to do …

Rider’s Story – Strength and Survival After Leukemia 

Rider is an athlete – he loves sports, especially football, so bumps and bruises here and there are nothing new. But when he noticed a bruise on his back from a minor fall during gym class was a lot bigger than he expected, and wasn’t going away, Rider got a little worried.   His mom, Jen noticed as well – and when her usually energetic 12-year-old …

What I’d tell myself about the first months of leukemia treatment

Do you ever have flashbacks of remembering how you felt during the first few weeks, even the first months after hearing the words, “your child has cancer”? I do. It is fresh in my mind how bewildered I felt and how alarmed I was by each side-effect that my daughter experienced. I wondered with despair, ‘Is this just our life now?’ ‘Is this our new daughter?’

Myla’s Story – Dancing After Leukemia

Seven-year-old Myla has always been a kind-hearted, active kid. She enjoys being silly, care-free and playing with her friends. So when her mom, Katie, noticed lumps on her daughter’s neck at a birthday party, she rushed her to urgent care as soon as she could.   Doctors ruled out strep throat and mono, and sent Myla home while they investigated further. Katie and Myla didn’t …

Fewer side-effects and no relapse – A leukemia researcher’s goal

"Studying new therapies to treat acute myeloid leukemia" graphic"

Today, when a child is diagnosed with leukemia, they’re told they are in for a long battle. Those years will include toxic treatments that can leave them with lifelong late effects. And for kids with a particularly rare form of leukemia, that’s all for a survival rate that is just a little better than a 6-in-10 chance of long-term survival. But Dr. Nathan Gossai and …

Harriet’s fight against leukemia

Harriet’s fight against leukemiaPreschooler Harriet had a tough year, but your unwavering support of research really lifts her family up, giving them hope as they enter a fresh year. DONATE

Cash’s Story – Fighting Acute Lymphoblastic Leukemia

“It’s an immediate life change,” Mona said. “There’s so much information being thrown at you at one time, and Cash was asking questions like why he couldn’t eat, when could we go home… he didn’t really understand what it all meant.” Three-year-old Cash has always been an active toddler – he played baseball and soccer, and was taking swimming and MMA lessons to burn off …

An “Achilles Heel” for Mixed-Lineage Leukemia

Maxim Pimkin, MD, PhD at Dana-Farber Cancer Institute in Boston is exploring how depleting two proteins in the body could save children with an especially dangerous kind of leukemia. Research helps kids like Harriet, who is fighting leukemia. Click to read “Spicy One -Harriet’s Story.” The problem Research has progressed exceedingly for children with acute lymphoblastic leukemia (ALL), but patients with acute myeloid leukemia (AML) …

Targeting ‘undruggable’ leukemia proteins

Ani Deshpande, PhD at Sanford Burnham Prebys Medical Discovery Institute in California is working to target previously ‘undruggable’ proteins in acute lymphoblastic leukemia. The problem: Research helps kids like Liam, who is fighting ALL. Click to read “Leukemia and Lightsabers – Liam’s Story.” Some types of childhood leukemia have two genes that fuse together to form a cancer-causing fusion protein. Some of these fusions proteins …