Investigating How to Make Chemotherapy More Effective for Kids with Osteosarcoma

David Largaespada

Jono Nagel Research Updates

Your support will help researchers investigate how to make chemotherapy effective for kids with spreading bone cancer.

Osteosarcoma is a deadly bone cancer that affects around 700 children and young adults in the United States each year. Though rare, the cancer has existed since the age of the dinosaurs with little treatment progress. When the bone cancer spreads to children’s lungs, they almost always die because the osteosarcoma cells no longer respond to chemotherapy.

How your donation helps:
David Largaespada, PhD, and his lab suspect there is a link between osteosarcoma’s chemotherapy resistance and its ability to spread and survive in distant parts of the body, such as the lungs. He plans to use CCRF funding to explore this link and investigate how to make the spreading form of osteosarcoma sensitive to chemotherapy again.

Support The Zach Sobiech Osteosarcoma Fund

Zach and his family helped start the Zach Sobiech Osteosarcoma Fund at Children’s Cancer Research Fund. Directed proceeds from his music and other fundraisers help researchers tackle osteosarcoma.

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